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TIPIN
Identifiers
Aliases	TIPIN, TIMELESS interacting protein
External IDs	OMIM: 610716; MGI: 1921571; HomoloGene: 32373; GeneCards: TIPIN; OMA:TIPIN - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q22.31 Start 66,336,191 bp End 66,386,746 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 C|9 34.6 cM Start 64,188,863 bp End 64,212,706 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle Achilles tendon secondary oocyte right testis left testis ganglionic eminence ventricular zone islet of Langerhans sperm Top expressed in fetal liver hematopoietic progenitor cell medial ganglionic eminence mandibular prominence otic placode abdominal wall embryo maxillary prominence somite primitive streak ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding DNA binding Cellular component intracellular membrane-bounded organelle nucleus nucleoplasm cytoplasm replication fork protection complex Biological process cell cycle phase transition mitotic intra-S DNA damage checkpoint signaling cellular response to DNA damage stimulus cell division DNA replication checkpoint signaling regulation of nuclear cell cycle DNA replication positive regulation of cell population proliferation cell cycle replication fork arrest replication fork protection DNA damage checkpoint signaling response to UV DNA replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54962 66131 Ensembl ENSG00000075131 ENSMUSG00000032397 UniProt Q9BVW5 Q91WA1 RefSeq (mRNA) NM_001289986 NM_017858 NM_001398281 NM_001398282 NM_001398283 NM_001398284 NM_001398285 NM_001398286 NM_001398287 NM_025372 NM_001324556 NM_001324557 NM_001324558 RefSeq (protein) NP_001276915 NP_060328 NP_001311485 NP_001311486 NP_001311487 NP_079648 Location (UCSC) Chr 15: 66.34 – 66.39 Mb Chr 9: 64.19 – 64.21 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene.

Interactions

TIPIN has been shown to interact with Replication protein A1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000075131 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032397 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gotter AL (Aug 2003). "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association". Journal of Molecular Biology. 331 (1): 167–76. doi:10.1016/S0022-2836(03)00633-8. PMID 12875843.
6. Yoshizawa-Sugata N, Masai H (Jan 2007). "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint". The Journal of Biological Chemistry. 282 (4): 2729–40. doi:10.1074/jbc.M605596200. PMID 17102137.
7. "Entrez Gene: TIPIN TIMELESS interacting protein".
8. Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.

Further reading

• Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.
• Gotter AL, Suppa C, Emanuel BS (Feb 2007). "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors". Journal of Molecular Biology. 366 (1): 36–52. doi:10.1016/j.jmb.2006.10.097. PMC 4151250. PMID 17141802.
• Chou DM, Elledge SJ (Nov 2006). "Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18143–7. Bibcode:2006PNAS..10318143C. doi:10.1073/pnas.0609251103. PMC 1654129. PMID 17116885.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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