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TLE2

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Protein-coding gene in the species Homo sapiens
TLE2
Identifiers
AliasesTLE2, ESG, ESG2, GRG2, transducin like enhancer of split 2, TLE family member 2, transcriptional corepressor
External IDsOMIM: 601041; MGI: 104635; HomoloGene: 20693; GeneCards: TLE2; OMA:TLE2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)
Chromosome 19 (human)Genomic location for TLE2Genomic location for TLE2
Band19p13.3Start2,997,639 bp
End3,047,635 bp
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)
Chromosome 10 (mouse)Genomic location for TLE2Genomic location for TLE2
Band10|10 C1Start81,410,395 bp
End81,426,679 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • cerebellar vermis

  • tibial nerve

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • left uterine tube

  • parotid gland

  • apex of heart

  • sural nerve
Top expressed in
  • cerebellar cortex

  • neural layer of retina

  • medullary collecting duct

  • lobe of cerebellum

  • cerebellar vermis

  • primary visual cortex

  • internal carotid artery

  • adrenal gland

  • superior frontal gyrus

  • molar
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7089

21886

Ensembl

ENSG00000065717

ENSMUSG00000034771

UniProt

Q04725

Q9WVB2

RefSeq (mRNA)

NM_001144761
NM_001144762
NM_001300846
NM_003260

NM_001252401
NM_019725

RefSeq (protein)

NP_001138233
NP_001138234
NP_001287775
NP_003251

NP_001239330
NP_062699

Location (UCSC)Chr 19: 3 – 3.05 MbChr 10: 81.41 – 81.43 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.

Interactions

TLE2 has been shown to interact with TLE1 and HES1.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000065717Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000034771Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Oct 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
  6. "Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)".
  7. ^ Grbavec, D; Lo R; Liu Y; Stifani S (Dec 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". Eur. J. Biochem. 258 (2). GERMANY: 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. ISSN 0014-2956. PMID 9874198.

Further reading

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