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TMBIM1
Identifiers
Aliases	TMBIM1, LFG3, MST100, MSTP100, RECS1, PP1201, transmembrane BAX inhibitor motif containing 1
External IDs	OMIM: 610364; MGI: 1916910; HomoloGene: 36404; GeneCards: TMBIM1; OMA:TMBIM1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 218,274,197 bp End 218,292,586 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C3 Start 74,327,406 bp End 74,344,781 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta body of pancreas body of stomach gastric mucosa right lung gallbladder skin of leg skin of abdomen popliteal artery Top expressed in epithelium of stomach pyloric antrum vestibular membrane of cochlear duct left colon ankle mucous cell of stomach ascending aorta aortic valve carotid body transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function death receptor binding Cellular component integral component of membrane lysosomal membrane endosome Golgi apparatus lysosome endosome membrane extracellular exosome membrane plasma membrane specific granule membrane intracellular membrane-bounded organelle Biological process negative regulation of Fas signaling pathway positive regulation of blood vessel remodeling negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of catalytic activity neutrophil degranulation negative regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64114 69660 Ensembl ENSG00000135926 ENSMUSG00000006301 UniProt Q969X1 Q8BJZ3 RefSeq (mRNA) NM_022152 NM_001321427 NM_001321428 NM_001321429 NM_001321430 NM_001321432 NM_001321433 NM_001321435 NM_001321436 NM_001321438 NM_027154 RefSeq (protein) NP_001308356 NP_001308357 NP_001308358 NP_001308359 NP_001308361 NP_001308362 NP_001308364 NP_001308365 NP_001308367 NP_071435 NP_081430 Location (UCSC) Chr 2: 218.27 – 218.29 Mb Chr 1: 74.33 – 74.34 Mb PubMed search
Wikidata
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Transmembrane BAX inhibitor motif-containing protein 1 is a protein that in humans is encoded by the TMBIM1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000135926 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000006301 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. "Entrez Gene: TMBIM1 transmembrane BAX inhibitor motif containing 1".

Further reading

• Yoshisue H, Suzuki K, Kawabata A, et al. (2002). "Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library". Atherosclerosis. 162 (2): 323–34. doi:10.1016/S0021-9150(01)00735-3. PMID 11996952.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hwang KC, Cui XS, Park SP, et al. (2005). "Identification of differentially regulated genes in bovine blastocysts using an annealing control primer system". Mol. Reprod. Dev. 69 (1): 43–51. doi:10.1002/mrd.20156. PMID 15278903. S2CID 26276700.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Zhao H, Ito A, Kimura SH, et al. (2007). "RECS1 deficiency in mice induces susceptibility to cystic medial degeneration". Genes Genet. Syst. 81 (1): 41–50. doi:10.1266/ggs.81.41. PMID 16607040.
• Zhao H, Ito A, Sakai N, et al. (2006). "RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation". Circ. J. 70 (5): 615–24. doi:10.1253/circj.70.615. PMID 16636500.

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