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TMEM219
Identifiers
Aliases	TMEM219, IGFBP-3R, transmembrane protein 219
External IDs	MGI: 1915992; HomoloGene: 19263; GeneCards: TMEM219; OMA:TMEM219 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 29,940,885 bp End 29,973,050 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 126,485,343 bp End 126,522,089 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right uterine tube C1 segment mucosa of transverse colon apex of heart body of stomach right adrenal cortex mucosa of ileum body of pancreas Top expressed in lacrimal gland granulocyte ascending aorta Paneth cell right kidney aortic valve spermatocyte proximal tubule seminal vesicula left lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component membrane integral component of membrane plasma membrane Biological process apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124446 68742 Ensembl ENSG00000149932 ENSMUSG00000060538 UniProt Q86XT9 Q9D123 RefSeq (mRNA) NM_001083613 NM_194280 NM_026827 NM_028389 NM_001374613 RefSeq (protein) NP_001077082 NP_919256 NP_001356617 NP_001356618 NP_001356619 NP_081103 NP_082665 NP_001361542 Location (UCSC) Chr 16: 29.94 – 29.97 Mb Chr 7: 126.49 – 126.52 Mb PubMed search
Wikidata
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Transmembrane protein 219 also known as insulin-like growth factor-binding protein 3 receptor or IGFBP-3R is a protein that in humans is encoded by the TMEM219 gene. IGFBP-3R acts as a cell death receptor for IGFBP3.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000149932 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000060538 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Transmembrane protein 219".
6. Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L, Fan L, Idowu M, Ware JL, Kim HS, Lee DY, Oh Y (September 2010). "Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer". J. Biol. Chem. 285 (39): 30233–46. doi:10.1074/jbc.M110.122226. PMC 2943278. PMID 20353938.

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