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TMIGD1

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Protein-coding gene in the species Homo sapiens
TMIGD1
Identifiers
AliasesTMIGD1, TMIGD, UNQ9372, transmembrane and immunoglobulin domain containing 1
External IDsMGI: 1913851; HomoloGene: 41641; GeneCards: TMIGD1; OMA:TMIGD1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for TMIGD1Genomic location for TMIGD1
Band17q11.2Start30,316,333 bp
End30,334,059 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for TMIGD1Genomic location for TMIGD1
Band11|11 B5Start76,792,985 bp
End76,807,413 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • rectum

  • mucosa of transverse colon

  • epithelium of colon

  • human kidney

  • smooth muscle tissue

  • duodenum

  • appendix

  • renal cortex

  • muscle layer of sigmoid colon

  • lymph node
Top expressed in
  • intestinal villus

  • right kidney

  • human kidney

  • ileum

  • Paneth cell

  • proximal tubule

  • jejunum

  • esophagus

  • submandibular gland

  • epithelium of small intestine
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

388364

66601

Ensembl

ENSG00000182271

ENSMUSG00000020839

UniProt

Q6UXZ0

Q9D7L8

RefSeq (mRNA)

NM_206832
NM_001319942

NM_025655
NM_001382246
NM_001382247

RefSeq (protein)

NP_001306871
NP_996663

NP_079931
NP_001369175
NP_001369176

Location (UCSC)Chr 17: 30.32 – 30.33 MbChr 11: 76.79 – 76.81 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene. TMIGD1 was discovered by the lab of Giancarlo Marra and later cloned by Nader Rahimi. Recent findings suggest functions in brush border formation (intestinal epithelium) and roles as tumor suppressor (kidney and intestine).

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000182271 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000020839 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Transmembrane and immunoglobulin domain containing 1". Retrieved 2017-02-20.
  6. Cattaneo E, Laczko E, Buffoli F, Zorzi F, Bianco MA, Menigatti M, et al. (May 2011). "Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)". EMBO Mol Med. 3 (6): 334–347. doi:10.1002/emmm.201100141. PMC 5839393. PMID 3377079.
  7. Meyer RD, Zou X, Ali M, Ersoy E, Bondzie PA, Lavaei M, et al. (February 2018). "TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer". Oncotarget. 9 (11): 9672–9684. doi:10.18632/oncotarget.23822. PMC 5839393. PMID 29515762.
  8. Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, et al. (October 2015). "TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury". The American Journal of Pathology. 185 (10): 2757–67. doi:10.1016/j.ajpath.2015.06.006. PMC 4607757. PMID 26342724.
  9. Thuering E, et al. (April 2023). "TMIGD1: Emerging functions of a tumor suppressor and adhesion receptor". Oncogene. 42 (22): 1777–1785. doi:10.1038/s41388-023-02696-5. PMC 10238269. PMID 37087524.
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