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TOE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FC6
Identifiers
Aliases	TOE1, hCaf1z, target of EGR1, member 1 (nuclear), PCH7, target of EGR1, exonuclease, TOE-1
External IDs	OMIM: 613931; MGI: 1915526; HomoloGene: 11823; GeneCards: TOE1; OMA:TOE1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.1 Start 45,340,052 bp End 45,343,973 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D1 Start 116,651,507 bp End 116,664,837 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb gonad parotid gland mucosa of transverse colon right lobe of thyroid gland left testis granulocyte right testis smooth muscle tissue rectum Top expressed in primitive streak renal corpuscle morula blastocyst spermatocyte epiblast superior cervical ganglion medullary collecting duct seminal vesicula ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5'-exoribonuclease activity protein binding metal ion binding nucleic acid binding poly(A)-specific ribonuclease activity snRNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm Cajal body nuclear speck nucleolus nucleoplasm nucleus nuclear body Biological process RNA phosphodiester bond hydrolysis, exonucleolytic snRNA 3'-end processing regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114034 68276 Ensembl ENSG00000132773 ENSMUSG00000028688 UniProt Q96GM8 Q9D2E2 RefSeq (mRNA) NM_025077 NM_026654 RefSeq (protein) NP_079353 NP_080930 Location (UCSC) Chr 1: 45.34 – 45.34 Mb Chr 4: 116.65 – 116.66 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Target of EGR1 protein 1 is a protein that in humans is encoded by the TOE1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000132773 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028688 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.
6. "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.

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