Misplaced Pages

TRIM38
Identifiers
Aliases	TRIM38, RNF15, RORET, tripartite motif containing 38
External IDs	MGI: 2684869; HomoloGene: 48427; GeneCards: TRIM38; OMA:TRIM38 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 25,962,802 bp End 25,991,231 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 23,953,896 bp End 23,975,511 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardia renal medulla pylorus nipple buccal mucosa cell superior surface of tongue ventral tegmental area external globus pallidus vena cava trigeminal ganglion Top expressed in morula blastocyst jejunum zygote duodenum colon primary oocyte secondary oocyte embryo spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding signal transducer activity metal ion binding protein binding transferase activity Cellular component cytosol intracellular anatomical structure Biological process immune system process interferon-gamma-mediated signaling pathway positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein ubiquitination positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10475 214158 Ensembl ENSG00000112343 ENSMUSG00000064140 UniProt O00635 Q5SZ99 RefSeq (mRNA) NM_006355 NM_001029935 RefSeq (protein) NP_006346 NP_001025106 Location (UCSC) Chr 6: 25.96 – 25.99 Mb Chr 13: 23.95 – 23.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Tripartite motif containing 38 is a protein that in humans is encoded by the TRIM38 gene.

Function

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. .

References

1. ^ GRCh38: Ensembl release 89: ENSG00000112343 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000064140 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tripartite motif containing 38". Retrieved 2018-03-21.

Further reading

• Liu X, Lei X, Zhou Z, Sun Z, Xue Q, Wang J, Hung T (February 2011). "Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase". Virol. J. 8: 61. doi:10.1186/1743-422X-8-61. PMC 3048563. PMID 21306652.
• Liu XL, Lei XB, Wang JW, Hong T (February 2011). "". Zhonghua Shi Yan He Lin Chuang Bing du Xue Za Zhi (in Chinese). 25 (1): 60–2. PMID 21789858.
• Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T (2012). "TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation". PLOS ONE. 7 (10): e46825. Bibcode:2012PLoSO...746825X. doi:10.1371/journal.pone.0046825. PMC 3466175. PMID 23056470.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 6 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 6
• Human chromosome 6 gene stubs