TRIM62, also called DEAR1 (for ductal epithelium–associated RING chromosome 1), is a protein in the tripartite motif family. In human it is encoded by the gene TRIM62. TRIM62 is involved in the morphogenesis of the mammary gland, and loss of TRIM62 gene expression in breast is associated with a higher risk of recurrence in early-onset breast cancer.
References
- ^ Lott ST, Chen N, Chandler DS, Yang Q, Wang L, et al. (2009). Minna JD (ed.). "DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer". PLOS Medicine. 6 (5): e1000068. doi:10.1371/journal.pmed.1000068. PMC 2673042. PMID 19536326.
- "TRIM62 tripartite motif-containing 62 ". Entrez Gene. Retrieved 1 Jun 2009.
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