TRPP3

Protein-coding gene in the species Homo sapiens

PKD2L2

Identifiers

PKD2L2, TRPP5, polycystin 2 like 2, transient receptor potential cation channel

External IDs

OMIM: 604669; MGI: 1858231; HomoloGene: 22812; GeneCards: PKD2L2; OMA:PKD2L2 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)

Band	5q31.2	Start	137,887,968 bp
Band	5q31.2	End	137,942,747 bp

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)

Band	18\|18 B1	Start	34,541,542 bp
Band	18\|18 B1	End	34,577,169 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

buccal mucosa cell

testicle

left testis

right testis

sperm

internal globus pallidus

gonad

muscle of thigh

Achilles tendon

Top expressed in

zygote

primary oocyte

secondary oocyte

spermatocyte

spermatid

granulocyte

seminiferous tubule

egg cell

supraoptic nucleus

muscle of thigh

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium ion binding calcium channel activity
Cellular component	integral component of membrane membrane
Biological process	ion transport detection of mechanical stimulus calcium ion transmembrane transport biological process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


27039


53871

Ensembl


ENSG00000078795


ENSMUSG00000014503

UniProt


Q9NZM6


Q9JLG4

RefSeq (mRNA)


NM_001258448 NM_001258449 NM_001300921 NM_014386


NM_001163004 NM_016927

RefSeq (protein)


NP_001245377 NP_001245378 NP_001287850 NP_055201


NP_001156476 NP_058623

Location (UCSC)

Chr 5: 137.89 – 137.94 Mb

Chr 18: 34.54 – 34.58 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

Polycystic kidney disease 2-like 2 protein (PKD2L2) also known as transient receptor potential polycystic 5 (TRPP5) is a protein that in humans is encoded by the PKD2L2 gene.

TRPP5 is a member of the transient receptor potential channel family of proteins.

References

^ GRCh38: Ensembl release 89: ENSG00000078795 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000014503 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ (December 1999). "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)". Eur. J. Hum. Genet. 7 (8): 860–72. doi:10.1038/sj.ejhg.5200383. PMID 10602361.

Li Q, Liu Y, Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation". FEBS Lett. 516 (1–3): 270–8. Bibcode:2002FEBSL.516..270L. doi:10.1016/S0014-5793(02)02513-9. PMID 11959145. S2CID 1812119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Stayner C, Zhou J (2001). "Polycystin channels and kidney disease". Trends Pharmacol. Sci. 22 (11): 543–6. doi:10.1016/S0165-6147(00)01832-0. PMID 11698076.
Guo L, Schreiber TH, Weremowicz S, et al. (2000). "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization". Genomics. 64 (3): 241–51. doi:10.1006/geno.2000.6131. PMID 10756092.

Membrane transport protein: ion channels (TC 1A)

Ca: Calcium channel

Ligand-gated

Inositol trisphosphate receptor
- 1
- 2
- 3
Ryanodine receptor
- 1
- 2
- 3

Voltage-gated

L-type/Ca_vα
- 1.1
- 1.2
- 1.3
- 1.4
N-type/Ca_vα2.2
P-type/Ca_vα
- 2.1
Q-type/Ca_vα2.1
R-type/Ca_vα2.3
T-type/Ca_vα
- 3.1
- 3.2
- 3.3

α₂δ-subunits
- 1
- 2
β-subunits
- β1
- β2
- β3
- β4
γ-subunits
- γ1
- γ2
- γ3
- γ4

Cation channels of sperm
- 1
- 2
- 3
- 4
Two-pore channel
- 1
- 2

Na: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H: Proton channel	HVCN1
M: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

This membrane protein–related article is a stub. You can help Misplaced Pages by expanding it.

Categories:

Misplaced Pages

See also

References

Further reading