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Drugs secreted in the kidney

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This is a table of drugs that are secreted in the kidney.

Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

Medication Location Acid or base anion or cation Percentage excreted
para-aminohippurate proximal tubule Acid anion
furosemide proximal tubule Acid anion 100-75
glucuronic acid-conjugates proximal tubule Acid
glycine conjugates proximal tubule Acid
indometacin proximal tubule Acid anion
methotrexate proximal tubule Acid 100-75
penicillin proximal tubule Acid anion 75-50
(benzylpenicillin)
probenecid proximal tubule Acid anion
sulphate conjugates proximal tubule Acid
thiazide diuretics proximal tubule Acid
uric acid proximal tubule Acid
amiloride proximal tubule Base cation
dopamine proximal tubule Base
histamine proximal tubule Base
mepacrine proximal tubule Base
morphine proximal tubule Base cation
pethidine proximal tubule Base
quaternary ammonium compounds proximal tubule Base
quinine proximal tubule Base cation
5-hydroxytryptamine (serotonin) proximal tubule Base
triamterene proximal tubule Base
gentamicin 100-75
atenolol 100-75
digoxin 100-75
cimetidine cation 75-50
tetracycline 75-50
(oxytetracycline)
neostigmine 75-50
propantheline ~50
tubocurarine ~50
acetazolamide proximal tubule anion
chlorothiazide proximal tubule anion
saccharin proximal tubule anion
salicylate proximal tubule anion
atropine proximal tubule cation
NMN proximal tubule cation
paraquat proximal tubule cation
procainamide proximal tubule cation
tetraethylammonium proximal tubule cation
chlorpromazine proximal tubule cation

References

  1. Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 112
  2. Unless else specified in table boxes, then ref is Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 802
  3. Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 113
  4. ^ Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 112
  5. ^ Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 802
Physiology of the kidneys and acid–base physiology
Creating urine
Secretion
Reabsorption
Filtration
Other functions
Hormones
Fluid balanceBody water: Intracellular fluid/Cytosol
Acid–base balance
  • Darrow Yannet diagram
  • Base excess
  • Davenport diagram
  • Anion gap (Delta ratio)
  • Winters's formula
  • Buffering
  • Assessment and measurement
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