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Table of volume of distribution for drugs

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This is a table of volume of distribution (Vd) for various medication. For comparison, those with a Vd L/kg body weight of less than 0.2 are mainly distributed in blood plasma, 0.2-0.7 mostly in the extracellular fluid and those with more than 0.7 are distributed throughout total body water.

Medication Vd L/kg body weight
heparin 0.05-0.1
insulin 0.05-0.1
warfarin 0.1-0.2
sulfamethoxazole 0.1-0.2
glibenclamide 0.1-0.2
atenolol 0.1-0.2
NXY-059 0.1-0.2
tubocurarine 0.2-0.4
theophylline 0.4-0.7
ethanol 0.7-0.9
neostigmine 0.7-0.9
phenytoin 0.7-0.9
methotrexate 1-2
indometacin 1-2
paracetamol 1-2
diazepam 1-2
lidocaine 1-2
glyceryl trinitrate 2-5
morphine 2-5
propranolol 2-5
digoxin 2-5
chlorpromazine 2-5
nortriptyline 2-5
chloroquine 200

References & footnotes

  1. ^ Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 103
  2. ^ Estimated with a body weight of 70 kg.
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