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Taxuspines is a class of taxanes, which are encountered in several species of the genus Taxus.

Typically, they are several types of them, named as taxuspines A ~ H and J. These new taxoids recently have been discovered in the Japanese yew, Taxus cuspidata. Taxuspines E ~ H and J (1 ~ 5), have been isolated from stems and leaves of the Japanese yew Taxus cuspidata Sieb. et Zucc.

Taxuspine E (1) exhibited potent cytotoxicity against KB cells.

See also

• Docetaxel
• Taxane
• Taxuyunnanine

References

1. CID 10417482 from PubChem
2. CID 5321744 from PubChem
3. CID 100991639 from PubChem
4. CID 5321746 from PubChem
5. Kobayashi, Jun'ichi; Inubushi, Akiko; Hosoyama, Hirokazu; Yoshida, Naotoshi; Sasaki, Takuma; Shigemori, Hideyuki (1995). "Taxuspines E ~ H and J, new taxoids from the Japanese yew Taxus cuspidata". Tetrahedron. 51 (21). Elsevier BV: 5971–5978. doi:10.1016/0040-4020(95)00255-7. ISSN 0040-4020.
6. Kobayashi, Juníchi; Ogiwara, Aya; Hosoyama, Hirokazu; Shigemori, Hideyuki; Yoshida, Naotoshi; Sasaki, Takuma; Li, Yin; Iwasaki, Shigeo; Naito, Mikihiko; Tsuruo, Takashi (1994). "Taxuspines A ~ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells". Tetrahedron. 50 (25). Elsevier BV: 7401–7416. doi:10.1016/s0040-4020(01)90470-3. ISSN 0040-4020.

External links

• Media related to taxanes at Wikimedia Commons

• Microtubule inhibitors
• Mitotic inhibitors
• Taxanes