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Teg49 small RNA

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Non-coding RNA
Teg49 sRNA
Predicted secondary structure and sequence conservation of Teg49 small RNA
Identifiers
RfamRF02696
Other data
Domain(s)Bacteria
GOGO:0009405
SOSO:0000370
PDB structuresPDBe

Teg49 is a non-coding RNA present in the extended promoter region of the staphylococcal accessory regulator sarA. It was identified by RNA-seq and confirmed by Northern blot. It is modulated by sigB (sarA regulator) and cshA (an ATP-dependant DEAD box RNA helicase) and it most likely contributes to virulence of S. aureus by modulating SarA expression.

References

  1. Cheung AL, Chien YT, Bayer AS (March 1999). "Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus". Infection and Immunity. 67 (3): 1331–1337. doi:10.1128/IAI.67.3.1331-1337.1999. PMC 96465. PMID 10024579.
  2. Oun S, Redder P, Didier JP, François P, Corvaglia AR, Buttazzoni E, Giraud C, Girard M, Schrenzel J, Linder P (January 2013). "The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus". RNA Biology. 10 (1): 157–165. doi:10.4161/rna.22899. PMC 3590232. PMID 23229022.
  3. Kim S, Reyes D, Beaume M, Francois P, Cheung A (October 2014). "Contribution of teg49 small RNA in the 5′ upstream transcriptional region of sarA to virulence in Staphylococcus aureus". Infection and Immunity. 82 (10): 4369–4379. doi:10.1128/IAI.02002-14. PMC 4187880. PMID 25092913.
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