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Anti-tetanus immunoglobulin

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(Redirected from Tetanus antitoxin) Medication made up of antibodies against the tetanus toxin Pharmaceutical compound
Anti-tetanus immunoglobulin
A vintage single-dose bottle of tetanus antitoxin manufactured by Sächsisches Serumwerk Dresden (now GlaxoSmithKline)
Clinical data
Trade namesHyperTET S/D, others
Other namestetanus immune globulin, tetanus antitoxin
AHFS/Drugs.comMonograph
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administration		IM
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Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of antibodies against the tetanus toxin. It is used to prevent tetanus in those who have a wound that is at high risk, have not been fully vaccinated with tetanus toxoid, or have HIV/AIDS. It is used to treat tetanus along with antibiotics and muscle relaxants. It is given by injection into a muscle. Part of the dose is injected at the site of the wound.

Common side effects include pain at the site of injection and fever. Allergic reactions including anaphylaxis may rarely occur. There is also a very low risk of the spread of infections such as viral hepatitis and HIV/AIDS with the human version. Use during pregnancy and lactation is acceptable. It is made from either human or horse blood plasma.

The immunoglobulin is categorized as immunoglobulin G (IgG). Since the tetanus toxin permanently binds to human tissues, only unbounded molecules can be neutralized by the immunoglobulin.

Use of the horse version became common in the 1910s, while the human version came into frequent use in the 1960s. It is on the World Health Organization's List of Essential Medicines. The human version may be unavailable in the developing world. The horse version is not typically used in the developed world due to the risk of serum sickness.

References

  1. ^ "Tetanus Immune Globulin". The American Society of Health-System Pharmacists. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  2. ^ Callison C, Nguyen H (2022), "Tetanus Prophylaxis", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32644434, retrieved 2022-08-08
  3. "Tetanus immune globulin Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  4. ^ "Tetanus Immune Globulin (Human)", Drugs and Lactation Database (LactMed), Bethesda (MD): National Library of Medicine (US), 2006, PMID 30000001, retrieved 2022-08-08
  5. ^ International Encyclopedia of Public Health (2 ed.). Academic Press. 2016. p. 161. ISBN 9780128037089. Archived from the original on 2017-01-09.
  6. Plotkin S, Orenstein WA, Offit PA (2012). Vaccines. Elsevier Health Sciences. pp. 103, 757. ISBN 978-1455700905. Archived from the original on 2017-01-09.
  7. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  8. World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  9. Fauci AS, Braunwald E, Kasper DL, Hauser S, Longo D, Jameson JL, Loscalzo J (2008). Harrison's Principles of Internal Medicine, 17th Edition. McGraw Hill Professional. p. 773. ISBN 9780071641142. Archived from the original on 2017-01-09.
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