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TIE1
Identifiers
Aliases	TIE1, JTK14, TIE, tyrosine kinase with immunoglobulin like and EGF like domains 1, LMPHM11
External IDs	OMIM: 600222; MGI: 99906; HomoloGene: 3957; GeneCards: TIE1; OMA:TIE1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 43,300,982 bp End 43,323,108 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.1|4 54.67 cM Start 118,328,388 bp End 118,347,258 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lung upper lobe of left lung right lobe of thyroid gland subcutaneous adipose tissue left lobe of thyroid gland body of uterus left ventricle right auricle tibial nerve Top expressed in cardiac muscle tissue of left ventricle left lung ankle joint right lung interventricular septum left lung lobe right lung lobe yolk sac atrium vein More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane cytoplasm receptor complex Biological process plasma membrane fusion response to retinoic acid phosphorylation in utero embryonic development vasculogenesis protein phosphorylation negative regulation of cell migration blood vessel development angiogenesis negative regulation of angiogenesis mesoderm development signal transduction peptidyl-tyrosine phosphorylation negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7075 21846 Ensembl ENSG00000066056 ENSMUSG00000033191 UniProt P35590 Q06806 RefSeq (mRNA) NM_001253357 NM_005424 NM_011587 RefSeq (protein) NP_001240286 NP_005415 NP_035717 Location (UCSC) Chr 1: 43.3 – 43.32 Mb Chr 4: 118.33 – 118.35 Mb PubMed search
Wikidata
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Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.

Function

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells and platelets. TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.

See also

• Angiopoietin § Tie pathway

References

1. ^ GRCh38: Ensembl release 89: ENSG00000066056 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000033191 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC 369613. PMID 1312667.
6. Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID 8570217.
7. Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". Journal of Vascular Research. 37 (6): 437–42. doi:10.1159/000054075. PMID 11146396. S2CID 43509019.
8. Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.

External links

• Receptor,+TIE-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• Genes on human chromosome 1
• Tyrosine kinase receptors
• Proteins