Tissue selectivity - Misplaced Pages

(Redirected from Tissue-selective) Disproportionate drug concentrations in differing tissues

Tissue selectivity is a topic in distribution (pharmacology) and property of some drugs. It refers to when a drug occurs in disproportionate concentrations and/or has disproportionate effects in specific tissues relative to other tissues. An example of such drugs are selective estrogen receptor modulators (SERM) like tamoxifen, which show estrogenic effects in some tissues and antiestrogenic effects in other tissues. Another example is peripherally-selective drugs, which do not cross the blood-brain-barrier into the central nervous system and hence are tissue-selective for the periphery.

References

Zweten (5 September 1997). Antihypertensive Drugs. CRC Press. p. 345. ISBN 9789057021220. The term "tissue selectivity" is used for an agent showing varying degrees of potency between tissues, with a preferential action in a given one.

Excitatory	Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist

Inhibitory	Antagonist Competitive antagonist Irreversible antagonist Physiological antagonist Inverse agonist Enzyme inhibitor

Activity at receptor	Mechanism of action Mode of action Binding Receptor (biochemistry) Desensitization (medicine)

Other effects of ligand	Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)

Analysis	Dose–response relationship Hill equation (biochemistry) Schild plot Del Castillo Katz model Cheng-Prussoff Equation Methods (Organ bath, Ligand binding assay, Patch clamp)

Metrics	Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Metrics	Loading dose Volume of distribution (Initial) Rate of infusion Onset of action Biological half-life Plasma protein binding Bioavailability

LADME	(L)ADME: (Liberation) Absorption Distribution Metabolism Excretion (Clearance)

Related
fields

Neuroscience and psychology	Neuropsychopharmacology Neuropharmacology Psychopharmacology Electrophysiology

Medicine	Clinical pharmacology Pharmacy Medicinal chemistry Pharmacoepidemiology

Biochemistry and genetics	Pharmacoinformatics Pharmacogenetics Pharmacogenomics

Toxicology	Pharmacotoxicology Neurotoxicology

Drug discovery	Classical pharmacology Reverse pharmacology

Other

Tolerance and resistance	Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance

Antimicrobial pharmacology	Antimicrobial pharmacodynamics Minimum inhibitory concentration Bacteriostatic Minimum bactericidal concentration Bactericide

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