Toffolo is a surname. Notable people with the surname include:
- Davide Toffolo (born 1965), Italian comic books writer
- Didier Toffolo (born 1959), French football player and manager
- Georgia Toffolo (born 1994) British television personality
- Harry Toffolo (born 1995), English football player
- Lino Toffolo (1934-2016), Italian actor and singer
- Rael Toffolo (born 1976), Brazilian musician
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