Tomassoni is an Italian surname. Notable people with the surname include:
- David Tomassoni (1952–2022), American politician
- Mirko Tomassoni (born 1969), Captain Regent of San Marino
- Ronn Tomassoni (born 1958), American ice hockey player and coach
- Thomas Tomassoni (1616–1654), Italian Roman Catholic bishop
See also
- Tomassoni awards, an Italian physics award
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