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Transaldolase 1

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Protein-coding gene in the species Homo sapiens
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TALDO1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1F05

Identifiers
AliasesTALDO1, TAL, TAL-H, TALDOR, TALH, transaldolase 1
External IDsOMIM: 602063; MGI: 1274789; HomoloGene: 4916; GeneCards: TALDO1; OMA:TALDO1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for TALDO1Genomic location for TALDO1
Band11p15.5Start747,415 bp
End765,012 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for TALDO1Genomic location for TALDO1
Band7|7 F5Start140,972,112 bp
End140,982,881 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • trabecular bone

  • blood

  • gingival epithelium

  • oocyte

  • monocyte

  • bone marrow

  • oral cavity

  • palpebral conjunctiva

  • secondary oocyte

  • granulocyte
Top expressed in
  • granulocyte

  • lacrimal gland

  • blood

  • brown adipose tissue

  • endothelial cell of lymphatic vessel

  • conjunctival fornix

  • retinal pigment epithelium

  • tunica adventitia of aorta

  • fetal liver hematopoietic progenitor cell

  • parotid gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6888

21351

Ensembl

ENSG00000177156

ENSMUSG00000025503

UniProt

P37837

Q93092

RefSeq (mRNA)

NM_006755

NM_011528

RefSeq (protein)

NP_006746

NP_035658

Location (UCSC)Chr 11: 0.75 – 0.77 MbChr 7: 140.97 – 140.98 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Transaldolase 1 is a protein that in humans is encoded by the TALDO1 gene.

Function

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. .

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000177156Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025503Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Transaldolase 1". Retrieved 2017-10-19.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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