Misplaced Pages

Trimetrexate

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
(Redirected from Trimetrexate glucuronate) Chemical compound Pharmaceutical compound
Trimetrexate
Clinical data
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa694019
ATC code
Pharmacokinetic data
BioavailabilityVD: 20-30 Liters
MetabolismOxidative O-demethylation, followed by conjugation with glucuronide or sulfate
Elimination half-life11 to 12 hours
Identifiers
IUPAC name
  • 5-methyl-6- quinazoline-2,4-diamine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H23N5O3
Molar mass369.425 g·mol
3D model (JSmol)
SMILES
  • n3c1c(c(c(cc1)CNc2cc(OC)c(OC)c(OC)c2)C)c(nc3N)N
InChI
  • InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)
  • Key:NOYPYLRCIDNJJB-UHFFFAOYSA-N
  (verify)

Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.

Uses

It has been used with leucovorin in treating pneumocystis pneumonia.

It has been investigated for use in treating leiomyosarcoma. It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma.

References

  1. Wong BK, Woolf TF, Chang T, Whitfield LR (1990). "Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog". Drug Metab. Dispos. 18 (6): 980–6. PMID 1981548.
  2. Sattler FR, Allegra CJ, Verdegem TD, et al. (January 1990). "Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia". J. Infect. Dis. 161 (1): 91–6. doi:10.1093/infdis/161.1.91. PMID 2136905.
  3. Smith HO, Blessing JA, Vaccarello L (January 2002). "Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group". Gynecol. Oncol. 84 (1): 140–4. doi:10.1006/gyno.2001.6482. PMID 11748990.
  4. Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol. 2002 Jun 15;20(12):2876-80.

External links

Antiparasitics – antiprotozoal agents – Chromalveolata antiparasitics (P01)
Alveo-
late
Apicom-
plexa
Conoidasida/
(Coccidiostats)
Cryptosporidiosis
Isosporiasis
Toxoplasmosis
Aconoidasida
Malaria
Individual
agents
Hemozoin
inhibitors
Aminoquinolines
4-Methanolquinolines
Other
Antifolates
DHFR inhibitors
Sulfonamides
Co-formulation
Sesquiterpene
lactones
Other
Combi-
nations
Fixed-dose (co-formulated) ACTs
Other combinations
(not co-formulated)
  • artesunate/mefloquine
  • artesunate/SP
  • quinine/clindamycin
  • quinine/doxycycline
  • quinine/tetracycline
Babesiosis
Cilio-
phora
Stramen-
opile


Stub icon

This antiinfective drug article is a stub. You can help Misplaced Pages by expanding it.

Categories: