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TSKU
Identifiers
Aliases	TSKU, E2IG4, LRRC54, TSK, tsukushi, small leucine rich proteoglycan
External IDs	OMIM: 608015; MGI: 2443855; HomoloGene: 41045; GeneCards: TSKU; OMA:TSKU - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.5 Start 76,782,251 bp End 76,798,153 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E1 Start 97,999,875 bp End 98,010,535 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua canal of the cervix ectocervix left uterine tube gastric mucosa right lobe of liver subcutaneous adipose tissue vagina skin of abdomen tibial nerve Top expressed in gallbladder respiratory epithelium olfactory epithelium lip ankle joint tail of embryo transitional epithelium of urinary bladder genital tubercle duodenum choroid plexus of fourth ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity Cellular component extracellular region extracellular space plasma membrane Biological process anterior commissure morphogenesis regulation of gene expression negative regulation of Wnt signaling pathway corpus callosum morphogenesis camera-type eye development ciliary body morphogenesis lateral ventricle development adenylate cyclase-modulating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25987 244152 Ensembl ENSG00000182704 ENSMUSG00000049580 UniProt Q8WUA8 Q8CBR6 RefSeq (mRNA) NM_001258210 NM_015516 NM_001318477 NM_001318478 NM_001318479 NM_001024619 NM_001168539 NM_001168540 NM_001168541 RefSeq (protein) NP_001245139 NP_001305406 NP_001305407 NP_001305408 NP_056331 NP_001019790 NP_001162011 NP_001162012 NP_001162013 Location (UCSC) Chr 11: 76.78 – 76.8 Mb Chr 7: 98 – 98.01 Mb PubMed search
Wikidata
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Tsukushi or tsukushin is an extracellular matrix protein of the small leucine rich proteoglycan (SLRP) family. In humans it is encoded by the TSKU gene.

Tsukushi is a non-canonical class IV SLRP. It is involved in early animal development.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000182704 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000049580 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tsukushi, small leucine rich proteoglycan". Retrieved 2018-02-01.
6. Iozzo, Renato V.; Schaefer, Liliana (March 2015). "Proteoglycan form and function: A comprehensive nomenclature of proteoglycans". Matrix Biology. 42: 11–55. doi:10.1016/j.matbio.2015.02.003. PMC 4859157. PMID 25701227.
7. Ohta, Kunimasa; Lupo, Giuseppe; Kuriyama, Sei; Keynes, Roger; Holt, Christine E.; Harris, William A.; Tanaka, Hideaki; Ohnuma, Shin-ichi (September 2004). "Tsukushi Functions as an Organizer Inducer by Inhibition of BMP Activity in Cooperation with Chordin". Developmental Cell. 7 (3): 347–358. doi:10.1016/j.devcel.2004.08.014. PMC 3793302. PMID 15363410.

Further reading

• Henke A, Grace OC, Ashley GR, Stewart GD, Riddick AC, Yeun H, O'Donnell M, Anderson RA, Thomson AA (2012). "Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer". PLOS ONE. 7 (8): e42516. Bibcode:2012PLoSO...742516H. doi:10.1371/journal.pone.0042516. PMC 3411755. PMID 22880013.

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• Genes on human chromosome 11
• Human chromosome 11 gene stubs
• Proteoglycans
• Extracellular matrix proteins