Tuberculosinol synthase

Tuberculosinol synthase (EC 3.1.7.8, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming). This enzyme catalyses the following chemical reaction

tuberculosinyl diphosphate + H₂O

\rightleftharpoons

This enzyme is present in Mycobacterium that cause tuberculosis.

References

Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB (February 2014). "Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c". Proceedings of the National Academy of Sciences of the United States of America. 111 (8): 2978–83. Bibcode:2014PNAS..111.2978L. doi:10.1073/pnas.1315883111. PMC 3939896. PMID 24516143.
Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T (2011). "Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome". Bioscience, Biotechnology, and Biochemistry. 75 (1): 75–81. doi:10.1271/bbb.100570. PMID 21228491. S2CID 42420573.
Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T (April 2011). "Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis". Organic & Biomolecular Chemistry. 9 (7): 2156–65. doi:10.1039/c0ob00884b. PMID 21290071.

Tuberculosinol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

3.1.1: Carboxylic
ester hydrolases

Exodeoxyribonuclease	RecBCD
Exoribonuclease	Oligonucleotidase

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme;see {{Restriction enzyme}} UvrABC endonuclease
Endoribonuclease	RNase III Drosha: Microprocessor complex Dicer: RNA-induced silencing complex RNase H 1 2A 2B 2C RNase P RNase A RNase Z RNase E 1 2 3 4/5 RNase T1
either deoxy- or ribo-	Nuclease S1 Mung bean nuclease Serratia marcescens nuclease Micrococcal nuclease

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)