Tupi may refer to:
- Tupi people of Brazil
- Tupi or Tupian languages, spoken in South America
- Tupi language, a dead Tupian language spoken by the Tupi people
- Tupi oil field off the coast of Brazil
- Tupi Paulista, a Brazilian municipality
- Tupi, South Cotabato, a Philippine municipality
- Tupi class, a Brazilian Navy version of the Type 209 submarine
- Tupi (submarine), the lead submarine of the class, commissioned in 1989
- Tupi Football Club, a Brazilian football (soccer) club
- Brazil national rugby union team, nicknamed Os Tupis
- Rede Tupi, the first Brazilian TV network (1950–1980)
- The tupi blackberry, a Mexican hybrid of the Comanche and Uruguai varieties
- Tupi (software), free and open source 2D animation software
- Tupà fermented cheese
See also
- Tupiniquim, an Amerindian tribe who live in Brazil
- Tupy (disambiguation)
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