Tupou is a common surname in Tonga. It may refer to:
- Anthony Tupou, Australian Rugby League player
- Bill Tupou, New Zealand Rugby League player
- Bowie Tupou, Australia boxer
- Daniel Tupou, Australian Rugby League player
- Fenuki Tupou, American football offensive lineman
- Josh Tupou, American football defensive lineman
- Tame Tupou, New Zealand rugby league footballer
- Tani Tupou, American football player
- Taniela Tupou, Australian Rugby Union player
- Will Tupou, New Zealand professional rugby footballer
- Willie Tupou, Australian rugby league footballer
- Several kings and queens of Tonga
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