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FES
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WQU, 2DCR, 3BKB, 3CBL, 3CD3, 4DYL, 4E93
Identifiers
Aliases	FES, FPS, Feline sarcoma oncogene, FES proto-oncogene, tyrosine kinase
External IDs	OMIM: 190030; MGI: 95514; HomoloGene: 37563; GeneCards: FES; OMA:FES - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q26.1 Start 90,883,695 bp End 90,895,776 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 D2|7 45.65 cM Start 80,027,504 bp End 80,037,694 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spleen granulocyte right lung upper lobe of left lung blood sural nerve apex of heart right lobe of liver left uterine tube Top expressed in granulocyte bone marrow stroma of bone marrow tibiofemoral joint ankle joint blood spleen mesenteric lymph nodes internal carotid artery body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity microtubule binding immunoglobulin receptor binding non-membrane spanning protein tyrosine kinase activity kinase activity protein binding phosphatidylinositol binding ATP binding lipid binding protein tyrosine kinase activity Cellular component cytoplasm cytosol Golgi apparatus membrane focal adhesion microtubule cytoskeleton extrinsic component of cytoplasmic side of plasma membrane plasma membrane cell junction cytoskeleton cytoplasmic vesicle Biological process phosphorylation regulation of vesicle-mediated transport regulation of cell motility multicellular organism development chemotaxis protein phosphorylation regulation of cell adhesion regulation of cell population proliferation microtubule bundle formation regulation of cell shape positive regulation of neuron projection development positive regulation of microtubule polymerization peptidyl-tyrosine autophosphorylation regulation of cell differentiation protein autophosphorylation peptidyl-tyrosine phosphorylation regulation of mast cell degranulation cell population proliferation innate immune response positive regulation of actin cytoskeleton reorganization positive regulation of myeloid cell differentiation epidermal growth factor receptor signaling pathway cell migration centrosome cycle cell adhesion positive regulation of monocyte differentiation cellular response to vitamin D Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2242 14159 Ensembl ENSG00000182511 ENSMUSG00000053158 UniProt P07332 P16879 RefSeq (mRNA) NM_001143783 NM_001143784 NM_001143785 NM_002005 NM_010194 RefSeq (protein) NP_001137255 NP_001137256 NP_001137257 NP_001996 NP_034324 Location (UCSC) Chr 15: 90.88 – 90.9 Mb Chr 7: 80.03 – 80.04 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene. FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.

Function

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.

Interactions

Feline sarcoma oncogene has been shown to interact with BCAR1 and BCR gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000182511 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000053158 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bowden DW, Akots G, Rothschild CB (Aug 1991). "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Research. 19 (15): 4311. doi:10.1093/nar/19.15.4311. PMC 328602. PMID 1870997.
6. "FES - Tyrosine-protein kinase Fes/Fps - Homo sapiens (Human) - FES gene & protein". www.uniprot.org. Retrieved 16 May 2022.
7. Craig AW (2012). "FES/FER kinase signaling in hematopoietic cells and leukemias". Frontiers in Bioscience. 17 (3): 861–75. doi:10.2741/3961. PMID 22201778.
8. "Entrez Gene: FES feline sarcoma oncogene".
9. Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA (Jan 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". The Journal of Biological Chemistry. 272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. PMID 8999909.
10. Lionberger JM, Smithgall TE (Feb 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Research. 60 (4): 1097–103. PMID 10706130.
11. Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE (Feb 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and Cellular Biology. 15 (2): 835–42. doi:10.1128/MCB.15.2.835. PMC 231961. PMID 7529874.

Further reading

• Smithgall TE, Rogers JA, Peters KL, Li J, Briggs SD, Lionberger JM, Cheng H, Shibata A, Scholtz B, Schreiner S, Dunham N (1998). "The c-Fes family of protein-tyrosine kinases". Critical Reviews in Oncogenesis. 9 (1): 43–62. doi:10.1615/critrevoncog.v9.i1.40. PMID 9754447.
• Jiang H, Harris MB, Rothman P (Jun 2000). "IL-4/IL-13 signaling beyond JAK/STAT". The Journal of Allergy and Clinical Immunology. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136.
• Greer P (Apr 2002). "Closing in on the biological functions of Fps/Fes and Fer". Nature Reviews Molecular Cell Biology. 3 (4): 278–89. doi:10.1038/nrm783. PMID 11994747. S2CID 22927394.

External links

• Overview of all the structural information available in the PDB for UniProt: P07332 (Tyrosine-protein kinase Fes/Fps) at the PDBe-KB.

• Biology

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