U21 or U-21 may refer to:
Naval vessels
- German submarine U-21, various vessels
- INS Jamuna (U21), a sloop of the Indian Navy
- SM U-21 (Austria-Hungary), a submarine of the Austro-Hungarian Navy
Other uses
- Beechcraft U-21 Ute, an American utility aircraft
- Great rhombihexahedron
- Small nucleolar RNA SNORD21
- Universitas 21, an international network of research-intensive universities
- Uppland Runic Inscription 21
See also
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