U43 may refer to:
Naval vessels
- German submarine U-43, various vessels
- HMS Bideford (U43), a sloop of the Royal Navy
- U-43-class submarine (Austria-Hungary), of the Austro-Hungarian Navy
- SM U-43 (Austria-Hungary), the lead boat of the class
Other uses
- Monticello Airport (Utah)
- Small ditrigonal dodecicosidodecahedron
- Small nucleolar RNA SNORD43
- U43, a line of the Dortmund Stadtbahn
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