Misplaced Pages

U46619

Names
Preferred IUPAC name (5Z)-7-{(1R,4S,5S,6R)-6--2-oxabicycloheptan-5-yl}hept-5-enoic acid
Identifiers
CAS Number	56985-40-1
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL357834
ECHA InfoCard	100.164.944
IUPHAR/BPS	1888
PubChem CID	5311493
CompTox Dashboard (EPA)	DTXSID601028475
SMILES CCCCC(O)/C=C/12OC(C2)1C/C=C\CCCC(O)=O
Properties
Chemical formula	C21H34O4
Molar mass	350.49 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is  ?) Infobox references

U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH₂ first prepared in 1975, and acts as a thromboxane A₂ (TP) receptor agonist. It potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations and exhibits many properties similar to thromboxane A₂, including shape change and aggregation of platelets and smooth muscle contraction. U46619 is a vasoconstrictor that mimics the hydroosmotic effect of vasopressin.

References

1. Bundy, G. L. (1975). "Synthesis of prostaglandin endoperoxide analogs". Tetrahedron Letters. 16 (24): 1957–1960. doi:10.1016/S0040-4039(00)72333-1.
2. Liel, N.; Mais, D.E.; Halushka, P.V (1987). "Binding of a thromboxane A2/prostaglandin H2 agonist U46619 to washed human platelets". Prostaglandins. 33 (6): 789–797. doi:10.1016/0090-6980(87)90107-9. PMID 2959986.
3. Burch, Ronald M.; Halushka, Perry V. (1983). "Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport". Journal of Pharmacology and Experimental Therapeutics. 224 (1): 108–17. PMID 6294273.

This molecular biology article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Prostaglandins
• Molecular biology stubs