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UAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JV1, 1JV3, 1JVD, 1JVG
Identifiers
Aliases	UAP1, AGX, AGX1, AGX2, SPAG2, UDP-N-acetylglucosamine pyrophosphorylase 1
External IDs	OMIM: 602862; MGI: 1334459; HomoloGene: 2342; GeneCards: UAP1; OMA:UAP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.3 Start 162,561,722 bp End 162,601,240 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H3 Start 169,969,507 bp End 170,002,526 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint parotid gland mucosa of sigmoid colon cartilage tissue gastric mucosa bronchial epithelial cell pericardium synovial membrane nasal epithelium left testis Top expressed in parotid gland morula lumbar spinal ganglion lacrimal gland submandibular gland left colon ankle joint cumulus cell right kidney conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity uridylyltransferase activity nucleotidyltransferase activity carbohydrate binding identical protein binding UDP-N-acetylglucosamine diphosphorylase activity Cellular component plasma membrane nucleoplasm cytoplasm cytosol Biological process UDP-N-acetylglucosamine metabolic process metabolism UDP-N-acetylglucosamine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6675 107652 Ensembl ENSG00000117143 ENSMUSG00000026670 UniProt Q16222 Q91YN5 RefSeq (mRNA) NM_003115 NM_001324113 NM_001324114 NM_001324115 NM_001324116 NM_001324117 NM_001388401 NM_001388402 NM_001399790 NM_001399791 NM_001399792 NM_001399793 NM_133806 NM_001305045 NM_001305046 RefSeq (protein) NP_001311042 NP_001311043 NP_001311044 NP_001311045 NP_001311046 NP_003106 NP_001291974 NP_001291975 NP_598567 Location (UCSC) Chr 1: 162.56 – 162.6 Mb Chr 1: 169.97 – 170 Mb PubMed search
Wikidata
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UDP-N-acetylhexosamine pyrophosphorylase is an enzyme that in humans is encoded by the UAP1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000117143 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026670 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.
6. Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.
7. "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".

Further reading

• Diekman AB, Olson G, Goldberg E (1998). "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa". Mol. Reprod. Dev. 50 (3): 284–93. doi:10.1002/(SICI)1098-2795(199807)50:3<284::AID-MRD4>3.0.CO;2-F. PMID 9621304. S2CID 25271682.
• Wang-Gillam A, Pastuszak I, Elbein AD (1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". J. Biol. Chem. 273 (42): 27055–7. doi:10.1074/jbc.273.42.27055. PMID 9765219.
• Peneff C, Ferrari P, Charrier V, et al. (2002). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". EMBO J. 20 (22): 6191–202. doi:10.1093/emboj/20.22.6191. PMC 125729. PMID 11707391.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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