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UDP-N-acetylglucosamine 6-dehydrogenase

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Class of enzymes
UDP-N-acetylglucosamine 6-dehydrogenase
Identifiers
EC no.1.1.1.136
CAS no.9054-83-5
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In enzymology, an UDP-N-acetylglucosamine 6-dehydrogenase (EC 1.1.1.136) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + 2 NAD + H2O {\displaystyle \rightleftharpoons } UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + 2 NADH + 2 H

The 3 substrates of this enzyme are UDP-N-acetyl-D-glucosamine, NAD, and H2O, whereas its 3 products are UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:NAD 6-oxidoreductase. Other names in common use include uridine diphosphoacetylglucosamine dehydrogenase, UDP-acetylglucosamine dehydrogenase, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, and UDP-GlcNAc dehydrogenase. This enzyme participates in aminosugars metabolism.

References

  • Fan DF, John CE, Zalitis J, Feingold DS (1969). "UDPacetylglucosamine dehydrogenase from Achromobacter georgiopolitanum". Arch. Biochem. Biophys. 135 (1): 45–9. doi:10.1016/0003-9861(69)90514-1. PMID 4312076.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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