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UPK2
Identifiers
Aliases	UPK2, UP2, UPII, uroplakin 2
External IDs	OMIM: 611558; MGI: 98913; HomoloGene: 4920; GeneCards: UPK2; OMA:UPK2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 118,925,164 bp End 118,958,559 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A5.2|9 24.84 cM Start 44,364,012 bp End 44,366,273 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urinary bladder ganglionic eminence nucleus accumbens mucosa of urinary bladder cingulate gyrus anterior cingulate cortex ventricular zone stromal cell of endometrium putamen caudate nucleus Top expressed in transitional epithelium of urinary bladder humerus Meckel's cartilage sphenoid bone fetal liver hematopoietic progenitor cell rib lesser wing of sphenoid bone seminal vesicula basisphenoid lobe of prostate More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome apical plasma membrane membrane Biological process multicellular organism development epithelial cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7379 22269 Ensembl ENSG00000110375 ENSMUSG00000041523 UniProt O00526 P38575 Q3SXK0 RefSeq (mRNA) NM_006760 NM_009476 RefSeq (protein) NP_006751 NP_033502 Location (UCSC) Chr 11: 118.93 – 118.96 Mb Chr 9: 44.36 – 44.37 Mb PubMed search
Wikidata
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Uroplakin-2 (UP2) is a protein that in humans is encoded by the UPK2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000110375 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000041523 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT (1998). "Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation". Cancer Res. 58 (6): 1291–7. PMID 9515818.
6. Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
7. "Entrez Gene: UPK2 uroplakin 2".

Further reading

• Lin JH, Wu XR, Kreibich G, Sun TT (1994). "Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane". J. Biol. Chem. 269 (3): 1775–84. doi:10.1016/S0021-9258(17)42095-3. PMID 7507484.
• Wu XR, Lin JH, Walz T, et al. (1994). "Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins". J. Biol. Chem. 269 (18): 13716–24. doi:10.1016/S0021-9258(17)36889-8. PMID 8175808.
• Yuasa T, Yoshiki T, Isono T, et al. (1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int. J. Urol. 6 (6): 286–92. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304. S2CID 43597402.
• Li SM, Zhang ZT, Chan S, et al. (1999). "Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder". J. Urol. 162 (3 Pt 1): 931–5. doi:10.1097/00005392-199909010-00093. PMID 10458411.
• Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 (4): 1047–50. doi:10.1016/S0002-9440(10)65206-6. PMC 1867018. PMID 10514386.
• Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum". Mol. Biol. Cell. 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMC 138628. PMID 12475947.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hirata H, Hisatomi H, Kawakita M, et al. (2004). "Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction". Oncol. Rep. 10 (4): 963–6. doi:10.3892/or.10.4.963. PMID 12792753.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chen F, Zeng F, Tong Q, et al. (2006). "Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector". J. Huazhong Univ. Sci. Technol. Med. Sci. 25 (2): 188–90, 211. doi:10.1007/BF02873573. PMID 16116969. S2CID 7772680.
• Jenkins D, Bitner-Glindzicz M, Malcolm S, et al. (2007). "Mutation analyses of Uroplakin II in children with renal tract malformations". Nephrol. Dial. Transplant. 21 (12): 3415–21. doi:10.1093/ndt/gfl465. PMID 17012268.

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