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Prefoldin subunit 3 (VBP-1), also Von Hippel–Lindau binding protein 1, is a prefoldin chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell. It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.

VBP-1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits, and is a member of the prefoldin-α subunit family. It is ubiquitously expressed in tissues, and is located in the cell nucleus and cytoplasm. The VBP1 gene is located at Xq28. Homologues are known to exist between human VBP-1 and proteins in mice, Drosophila and C. elegans.

See also

• Von Hippel–Lindau tumor suppressor
• Von Hippel–Lindau disease
• Eugen von Hippel
• Arvid Lindau

References

1. "UniProt". beta.uniprot.org. Retrieved 27 March 2022.
2. Tsuchiya H, Iseda T, Hino O (1996). "Identification of a novel protein (VBP-1) binding to the von Hippel–Lindau (VHL) tumor suppressor gene product". Cancer Research. 56 (13): 2881–5. PMID 8674032.
3. ^ "GenAtlas report: VBP1". 2003-01-17. Retrieved 2007-07-17.
4. ^ "NiceProt report: P61758 (Prefoldin 3, human)". 2007-07-10. Retrieved 2007-07-17.
5. Brinke A, Green PM, Giannelli F (1997). "Characterization of the gene (VBP1) and transcript for the von Hippel–Lindau binding protein and isolation of the highly conserved murine homologue". Genomics. 45 (1): 105–12. doi:10.1006/geno.1997.4902. PMID 9339366.

External links

• von+Hippel-Lindau+binding+protein+1,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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