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VGLL3
Identifiers
Aliases	VGLL3, VGL-3, VGL3, Vestigial-like family member 3, vestigial like family member 3
External IDs	OMIM: 609980; MGI: 1920819; HomoloGene: 53442; GeneCards: VGLL3; OMA:VGLL3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p12.1 Start 86,876,388 bp End 86,991,149 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C1.3 Start 65,612,143 bp End 65,663,254 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung saphenous vein placenta parietal pleura superficial temporal artery Achilles tendon pericardium germinal epithelium stromal cell of endometrium visceral pleura Top expressed in sciatic nerve gastrula calvaria umbilical cord decidua stroma of bone marrow skin of external ear ascending aorta skin of abdomen transitional epithelium of urinary bladder More reference expression data BioGPS n/a
Gene ontology Molecular function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 389136 73569 Ensembl ENSG00000206538 ENSMUSG00000091243 UniProt A8MV65 P85442 RefSeq (mRNA) NM_016206 NM_001320493 NM_001320494 NM_028572 NM_001368760 NM_001368761 RefSeq (protein) NP_001307422 NP_001307423 NP_057290 NP_082848 NP_001355689 NP_001355690 Location (UCSC) Chr 3: 86.88 – 86.99 Mb Chr 16: 65.61 – 65.66 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Vestigial-like family member 3 is a protein that in humans is encoded by the VGLL3 gene.

This protein is one of four mammalian homologs (VGLL1-4) of the vestigial gene found in the fruit fly Drosophila. VGLL3 functions as a transcription coregulator by binding to TEA domain (TEAD) transcription factors (TEAD1, TEAD2, TEAD3, TEAD4 ) through its TDU motif. VGLL3 has been implicated in various biological processes including myogenesis (formation of muscle tissue), cell proliferation, and cancer progression. VGLL3 can also promote epithelial-to-mesenchymal transition (EMT) and cell motility in certain cancer types, suggesting it may play a role in tumor development and metastasis.

See also

• Vestigial like family member 4

References

1. ^ GRCh38: Ensembl release 89: ENSG00000206538 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000091243 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Vestigial-like family member 3".
6. ^ Yamaguchi N (2020). "Multiple Roles of Vestigial-Like Family Members in Tumor Development". Frontiers in Oncology. 10: 1266. doi:10.3389/fonc.2020.01266. PMC 7393262. PMID 32793503.
7. ^ Hori N, Takakura Y, Sugino A, Iwasawa S, Nomizo K, Yamaguchi N, et al. (May 2022). "Vestigial-like family member 3 stimulates cell motility by inducing high-mobility group AT-hook 2 expression in cancer cells". Journal of Cellular and Molecular Medicine. 26 (9): 2686–2697. doi:10.1111/jcmm.17279. PMC 9077286. PMID 35366053.

Further reading

• Tao S, Wang Z, Feng J, Hsu FC, Jin G, Kim ST, et al. (March 2012). "A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants". Carcinogenesis. 33 (3): 598–603. doi:10.1093/carcin/bgr316. PMC 3291863. PMID 22219177.
• Gambaro K, Quinn MC, Wojnarowicz PM, Arcand SL, de Ladurantaye M, Barrès V, et al. (June 2013). "VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer". Molecular Oncology. 7 (3): 513–30. doi:10.1016/j.molonc.2012.12.006. PMC 5528482. PMID 23415753.
• Zhou W, Chen H, Zhang L (March 2009). "The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor" (PDF). BMB Reports. 42 (3): 154–9. doi:10.5483/bmbrep.2009.42.3.154. PMID 19336002.
• Halperin DS, Pan C, Lusis AJ, Tontonoz P (February 2013). "Vestigial-like 3 is an inhibitor of adipocyte differentiation". Journal of Lipid Research. 54 (2): 473–81. doi:10.1194/jlr.M032755. PMC 3541706. PMID 23152581.
• Hélias-Rodzewicz Z, Pérot G, Chibon F, Ferreira C, Lagarde P, Terrier P, et al. (December 2010). "YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas". Genes, Chromosomes & Cancer. 49 (12): 1161–71. doi:10.1002/gcc.20825. PMID 20842732. S2CID 205828045.
• Wang L, Lu W, Chen YG, Zhou XM, Gu JR (December 1999). "Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display". World Journal of Gastroenterology. 5 (6): 533–534. doi:10.3748/wjg.v5.i6.533. PMC 4688801. PMID 11819507.
• Maeda T, Chapman DL, Stewart AF (December 2002). "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation". The Journal of Biological Chemistry. 277 (50): 48889–98. doi:10.1074/jbc.M206858200. PMID 12376544.

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