Van Asperen is a Dutch surname meaning "from Asperen". It may refer to:
- Aart van Asperen (b. 1956), Dutch television director
- Bob van Asperen (b. 1947), Dutch harpsichordist
- Eelco van Asperen (1965-2013), Dutch computer scientist
- Gerrit Verdooren van Asperen (1757-1824), Dutch naval officer
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