Villano may refer to:
- Vittorio Villano (born 1988), Belgian footballer
- Villano de las Encartaciones, Spanish dog breed
- Any of the members of the Mendoza professional wrestling family who wrestled under the ring name "Villano":
- Villano I (1950–2001), real name José de Jesús Díaz Mendoza
- Villano II (1949–1989), real name José Alfredo Díaz Mendoza
- Villano III (1952–2018), real name Arturo Díaz Mendoza
- Villano IV (born 1965), real name Thomas Díaz Mendoza
- Villano V (born 1962), real name Raymundo Díaz Mendoza, Jr.
- Villanos (band), an Argentinian band
- Villano III Jr. (born 1998), Mexican third-generation luchador enmascarado
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