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Vomilenine reductase

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vomilenine reductase
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EC no.1.5.1.32
CAS no.462127-03-3
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In enzymology, a vomilenine reductase (EC 1.5.1.32) is an enzyme that catalyzes the chemical reaction

1,2-dihydrovomilenine + NADP {\displaystyle \rightleftharpoons } vomilenine + NADPH + H

Thus, the two substrates of this enzyme are 1,2-dihydrovomilenine and NADP, whereas its 3 products are vomilenine, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydrovomilenine:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

References

  • von Schumann G, Gao S, Stockigt J (2002). "Vomilenine reductase--a novel enzyme catalyzing a crucial step in the biosynthesis of the therapeutically applied antiarrhythmic alkaloid ajmaline". Bioorg. Med. Chem. 10 (6): 1913–8. doi:10.1016/S0968-0896(01)00435-7. PMID 11937349.
Oxidoreductases: CH-NH (EC 1.5)
1.5.1: NAD or NADP acceptor
1.5.3: oxygen acceptor
1.5.5: quinone acceptor
1.5.99
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