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DCAF11
Identifiers
Aliases	DCAF11, PRO2389, WDR23, GL014, DDB1 and CUL4 associated factor 11
External IDs	OMIM: 613317; MGI: 90168; HomoloGene: 11886; GeneCards: DCAF11; OMA:DCAF11 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q12 Start 24,114,195 bp End 24,125,242 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 C3|14 28.19 cM Start 55,797,463 bp End 55,807,522 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum body of pancreas sural nerve skeletal muscle tissue blood granulocyte muscle of leg bone marrow gastrocnemius muscle Top expressed in left lobe of liver ankle vestibular membrane of cochlear duct right kidney muscle of thigh transitional epithelium of urinary bladder temporal muscle right ventricle sternocleidomastoid muscle triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Cul4-RING E3 ubiquitin ligase complex nucleoplasm Biological process post-translational protein modification protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80344 28199 Ensembl ENSG00000100897 ENSG00000284796 ENSMUSG00000022214 UniProt Q8TEB1 Q91VU6 RefSeq (mRNA) NM_001163484 NM_025230 NM_181357 NM_001199009 NM_133734 RefSeq (protein) NP_001156956 NP_079506 NP_852002 NP_001185938 NP_598495 Location (UCSC) Chr 14: 24.11 – 24.13 Mb Chr 14: 55.8 – 55.81 Mb PubMed search
Wikidata
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DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.

DCAF11 is a WD40 repeat protein, containing seven repeats of the closed circular solenoid protein domain WD40. WDR-23 exists in two spatially distinct isoforms produced by alternative splicing, a cytoplasmic WDR-23A and nuclear WDR-23B. Nuclear and cytoplasmic versions of WDR-23 have distinct roles.

References

1. ^ ENSG00000284796 GRCh38: Ensembl release 89: ENSG00000100897, ENSG00000284796 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022214 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Choe KP, Przybysz AJ, Strange K (May 2009). "The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans". Molecular and Cellular Biology. 29 (10): 2704–2715. doi:10.1128/MCB.01811-08. PMC 2682033. PMID 19273594.
6. Spatola BN, Lo JY, Wang B, Curran SP (August 2019). "Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates". Scientific Reports. 9 (1): 11783. Bibcode:2019NatSR...911783S. doi:10.1038/s41598-019-48286-y. PMC 6692315. PMID 31409866. This article incorporates text from this source, which is available under the CC BY 4.0 license.

Further reading

• Siswanto FM, Oguro A, Arase S, Imaoka S (October 2020). "WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes". Drug Metabolism and Pharmacokinetics. 35 (5): 441–455. doi:10.1016/j.dmpk.2020.06.007. PMID 32839090. S2CID 221307354.
• Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, et al. (April 2021). "DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras". Journal of the American Chemical Society. 143 (13): 5141–5149. doi:10.1021/jacs.1c00990. PMC 8309050. PMID 33783207.
• Le R, Huang Y, Zhang Y, Wang H, Lin J, Dong Y, et al. (April 2021). "Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells". Cell Stem Cell. 28 (4): 732–747.e9. doi:10.1016/j.stem.2020.11.018. PMID 33357405. S2CID 229693249.
• Wang K, Liu Y, Yu Z, Gu B, Hu J, Huang L, et al. (November 2021). "Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle". Cell Reports. 37 (6): 109987. doi:10.1016/j.celrep.2021.109987. PMID 34758320. S2CID 243952009.
• Siswanto FM, Sakuma R, Oguro A, Imaoka S (August 2022). "Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 77 (8): 1503–1516. doi:10.1093/gerona/glac062. PMID 35279029.

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