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WD repeat-containing protein 77

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(Redirected from WDR77) Protein-coding gene in the species Homo sapiens

WDR77
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4GQB, 4X60, 4X61, 4X63, 5EMJ, 5EML, 5EMM, 5FA5, 5EMK, 5C9Z

Identifiers
AliasesWDR77, MEP-50, MEP50, Nbla10071, p44, p44/Mep50, HKMT1069, WD repeat domain 77
External IDsOMIM: 611734; MGI: 1917715; HomoloGene: 11466; GeneCards: WDR77; OMA:WDR77 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for WDR77Genomic location for WDR77
Band1p13.2Start111,439,890 bp
End111,449,256 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for WDR77Genomic location for WDR77
Band3|3 F2.2Start105,866,685 bp
End105,877,353 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • apex of heart

  • gastrocnemius muscle

  • right adrenal cortex

  • muscle of thigh

  • mucosa of esophagus

  • body of stomach

  • left ventricle

  • left adrenal gland

  • rectum
Top expressed in
  • primitive streak

  • epiblast

  • somite

  • tail of embryo

  • abdominal wall

  • endocardial cushion

  • Gonadal ridge

  • embryo

  • embryo

  • mandibular prominence
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79084

70465

Ensembl

ENSG00000116455

ENSMUSG00000000561

UniProt

Q9BQA1

Q99J09

RefSeq (mRNA)

NM_024102
NM_001317062
NM_001317063
NM_001317064

NM_027432

RefSeq (protein)

NP_001303991
NP_001303992
NP_001303993
NP_077007

NP_081708

Location (UCSC)Chr 1: 111.44 – 111.45 MbChr 3: 105.87 – 105.88 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.

Interactions

WD repeat-containing protein 77 has been shown to interact with CTDP1 and Protein arginine methyltransferase 5.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000116455Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000000561Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J Biol Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
  6. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  7. "Entrez Gene: WDR77 WD repeat domain 77".
  8. Licciardo P, Amente Stefano, Ruggiero Luca, Monti Maria, Pucci Piero, Lania Luigi, Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. 31 (3). England: 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9BQA1 (Methylosome protein 50) at the PDBe-KB.
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