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WIPF2
Identifiers
Aliases	WIPF2, WICH, WIRE, WAS/WASL interacting protein family member 2
External IDs	OMIM: 609692; MGI: 1924462; HomoloGene: 15777; GeneCards: WIPF2; OMA:WIPF2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 40,219,304 bp End 40,284,136 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 98,754,464 bp End 98,795,866 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell frontal pole lower lobe of lung nipple Brodmann area 46 internal globus pallidus Brodmann area 10 optic nerve paraflocculus of cerebellum Top expressed in transitional epithelium of urinary bladder genital tubercle subiculum superior colliculus ventral tegmental area tail of embryo central gray substance of midbrain medial geniculate nucleus Region I of hippocampus proper dorsomedial hypothalamic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding actin filament binding Cellular component cytoplasm cytosol cytoskeleton nucleoplasm plasma membrane actin filament actin cortical patch Biological process Fc-gamma receptor signaling pathway involved in phagocytosis actin cortical patch assembly endocytosis actin filament-based movement positive regulation of actin nucleation actin cortical patch localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147179 68524 Ensembl ENSG00000171475 ENSMUSG00000038013 UniProt Q8TF74 Q6PEV3 RefSeq (mRNA) NM_133264 NM_197940 RefSeq (protein) NP_573571 NP_922922 Location (UCSC) Chr 17: 40.22 – 40.28 Mb Chr 11: 98.75 – 98.8 Mb PubMed search
Wikidata
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WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000171475 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000038013 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Aspenstrom P (Sep 2002). "The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor". Exp Cell Res. 279 (1): 21–33. doi:10.1006/excr.2002.5576. PMID 12213210.
6. Kato M, Miki H, Kurita S, Endo T, Nakagawa H, Miyamoto S, Takenawa T (Feb 2002). "WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation". Biochem Biophys Res Commun. 291 (1): 41–7. doi:10.1006/bbrc.2002.6406. PMID 11829459.
7. ^ "Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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