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WSB1

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Protein-coding gene in the species Homo sapiens
WSB1
Identifiers
AliasesWSB1, SWIP1, WSB-1, WD repeat and SOCS box containing 1
External IDsOMIM: 610091; MGI: 1926139; HomoloGene: 9218; GeneCards: WSB1; OMA:WSB1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for WSB1Genomic location for WSB1
Band17q11.1Start27,294,076 bp
End27,315,926 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for WSB1Genomic location for WSB1
Band11|11 B5Start79,130,198 bp
End79,145,497 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • gastric mucosa

  • lower lobe of lung

  • inferior ganglion of vagus nerve

  • tibial nerve

  • Region I of hippocampus proper

  • tibial arteries

  • canal of the cervix

  • endothelial cell

  • left uterine tube
Top expressed in
  • medullary collecting duct

  • cumulus cell

  • neural tube

  • dorsomedial hypothalamic nucleus

  • pineal gland

  • vas deferens

  • dermis

  • paraventricular nucleus of hypothalamus

  • ventral tegmental area

  • Gonadal ridge
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26118

78889

Ensembl

ENSG00000109046

ENSMUSG00000017677

UniProt

Q9Y6I7

O54927

RefSeq (mRNA)

NM_015626
NM_134264
NM_134265
NM_001348350

NM_001042565
NM_019653

RefSeq (protein)

NP_056441
NP_599027
NP_001335279

NP_001036030
NP_062627

Location (UCSC)Chr 17: 27.29 – 27.32 MbChr 11: 79.13 – 79.15 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000109046Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000017677Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vasiliauskas D, Hancock S, Stern CD (Aug 1999). "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development". Mech Dev. 82 (1–2): 79–94. doi:10.1016/S0925-4773(99)00014-3. PMID 10354473. S2CID 15357835.
  6. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  7. ^ "Entrez Gene: WSB1 WD repeat and SOCS box-containing 1".

Further reading

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