West Second Street Historic District may refer to:
- West Second Street Historic District (Mesa, Arizona), listed on the National Register of Historic Places in Maricopa County, Arizona
- West Second Street Historic District (Ashland, Wisconsin), listed on the National Register of Historic Places in Ashland County, Wisconsin
See also
- Second Street Historic District (disambiguation)
- West Second Street Residential Historic District, Hastings, Minnesota, U.S.
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