Whitesell is a surname. Notable people with the surname include:
- Josh Whitesell (born 1982), American major league baseball player
- Patrick Whitesell (born 1965), American talent agent and co-CEO of WME Entertainment
- Sean Whitesell (1963–2015), American film and television actor
- Brian Whitesell (born 1964), American auto racing team manager
- Christopher Whitesell, American television soap opera writer
- Jim Whitesell (born 1959), American college basketball coach
- John Whitesell, American television and film director
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