William O'Grady may refer to:
- William O'Grady (cleric) (1801–1859), Irish religious leader
- William O'Grady (footballer) (fl. 1948), Irish Olympic footballer
- William O'Grady (linguist) (born 1952), American linguist, known for work in syntax, acquisition, and Korean
- William John O'Grady (died 1840), Irish Catholic priest and journalist in Upper Canada
See also
- William O'Grady Haly, British army officer
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