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XPOT
Identifiers
Aliases	XPOT, XPO3, exportin for tRNA
External IDs	OMIM: 603180; MGI: 1920442; HomoloGene: 38291; GeneCards: XPOT; OMA:XPOT - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q14.2 Start 64,404,392 bp End 64,451,125 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D2 Start 121,423,285 bp End 121,462,237 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium endothelial cell Brodmann area 23 islet of Langerhans Achilles tendon bone marrow cells ventricular zone body of pancreas middle temporal gyrus ganglionic eminence Top expressed in ureter lacrimal gland calvaria renal corpuscle fossa condyle parotid gland hair follicle substantia nigra medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tRNA binding RNA binding Cellular component cytoplasm nuclear matrix nuclear pore nucleus nucleoplasm cytosol Biological process intracellular protein transport tRNA re-export from nucleus tRNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11260 73192 Ensembl ENSG00000184575 ENSMUSG00000034667 UniProt O43592 Q9CRT8 RefSeq (mRNA) NM_007235 NM_001081056 NM_001359618 NM_001401044 NM_001401045 RefSeq (protein) NP_009166 NP_001074525 NP_001346547 NP_001387973 NP_001387974 Location (UCSC) Chr 12: 64.4 – 64.45 Mb Chr 10: 121.42 – 121.46 Mb PubMed search
Wikidata
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Exportin-T is a protein that in humans is encoded by the XPOT gene.

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000184575 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000034667 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell. 1 (3): 359–69. doi:10.1016/S1097-2765(00)80036-2. PMID 9660920.
6. Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA". Curr Biol. 8 (6): 305–14. doi:10.1016/S0960-9822(98)70130-7. PMID 9512417. S2CID 17803674.
7. ^ "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)".

Further reading

• Arts GJ, Kuersten S, Romby P, et al. (1999). "The role of exportin-t in selective nuclear export of mature tRNAs". EMBO J. 17 (24): 7430–41. doi:10.1093/emboj/17.24.7430. PMC 1171087. PMID 9857198.
• Kruse C, Willkomm DK, Grünweller A, et al. (2000). "Export and transport of tRNA are coupled to a multi-protein complex". Biochem. J. 346 (1): 107–15. doi:10.1042/0264-6021:3460107. PMC 1220829. PMID 10657246.
• Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily". J. Biol. Chem. 275 (51): 40163–8. doi:10.1074/jbc.M006242200. hdl:11858/00-001M-0000-0015-3D4E-B. PMID 11024021.
• Kuersten S, Arts GJ, Walther TC, et al. (2002). "Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains". Mol. Cell. Biol. 22 (16): 5708–20. doi:10.1128/MCB.22.16.5708-5720.2002. PMC 133969. PMID 12138183.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki T, Koyama Y, Hayakawa S, et al. (2006). "1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells". Biomed. Res. 27 (2): 89–92. doi:10.2220/biomedres.27.89. PMID 16707848.
• Li S, Sprinzl M (2007). "Interaction of immobilized human exportin-t with calf liver tRNA". RNA Biol. 3 (4): 145–9. doi:10.4161/rna.3.4.3679. PMID 17224653.

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