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In enzymology, a xenobiotic-transporting ATPase (EC 3.6.3.44) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + xenobioticin ${\displaystyle \rightleftharpoons }$ ADP + phosphate + xenobioticout

The 3 substrates of this enzyme are ATP, H₂O, and xenobiotic, whereas its 3 products are ADP, phosphate, and xenobiotic.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (xenobiotic-exporting). Other names in common use include multidrug-resistance protein, MDR protein, P-glycoprotein, pleiotropic-drug-resistance protein, PDR protein, steroid-transporting ATPase, and ATP phosphohydrolase (steroid-exporting).

References

• Bellamy WT (1996). "P-glycoproteins and multidrug resistance". Annu. Rev. Pharmacol. Toxicol. 36: 161–83. doi:10.1146/annurev.pa.36.040196.001113. PMID 8725386.
• Oude Elferink RP; Ottenhoff, R; Van Wijland, MJ; Van Nieuwkerk, C; Groen, AK; Oude Elferink, RP (1996). "Influence of bile salts on hepatic mdr2 P-glycoprotein expression". Adv. Enzyme. Regul. 36: 351–63. doi:10.1016/0065-2571(95)00019-4. PMID 8869755.
• Keppler D, Konig J, Buchler M (1997). "The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes". Adv. Enzyme. Regul. 37: 321–33. doi:10.1016/S0065-2571(96)00013-1. PMID 9381978.
• Loe DW, Deeley RG, Cole SP (1998). "Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione". Cancer Res. 58 (22): 5130–6. PMID 9823323.
• van Veen HW, Konings WN (1998). "The ABC family of multidrug transporters in microorganisms". Biochim. Biophys. Acta. 1365 (1–2): 31–6. doi:10.1016/S0005-2728(98)00039-5. PMID 9693718.
• Griffiths JK; Sansom CE. "The Transporter Factsbook, Academic Press, San Diego, 1998". {{cite journal}}: Cite journal requires |journal= (help)
• Prasad R, De Wergifosse P, Goffeau A, Balzi E (1995). "Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals". Curr. Genet. 27 (4): 320–9. doi:10.1007/BF00352101. PMID 7614555. S2CID 29807003.
• Yamasaki M; Taguchi, Y; Arioka, M; Kadokura, H; Takatsuki, A; Yoda, K; Yamasaki, M (1995). "bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily". J. Bacteriol. 177 (6): 1536–43. doi:10.1128/jb.177.6.1536-1543.1995. PMC 176770. PMID 7883711.
• Mahe Y, Lemoine Y, Kuchler K (1996). "The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo". J. Biol. Chem. 271 (41): 25167–72. doi:10.1074/jbc.271.41.25167. PMID 8810273.

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