Zinc-activated ion channel - Misplaced Pages

(Redirected from ZACN) Protein-coding gene in the species Homo sapiens

ZACN

Identifiers

ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel

External IDs

OMIM: 610935; HomoloGene: 52296; GeneCards: ZACN; OMA:ZACN - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q25.1	Start	76,071,961 bp
Band	17q25.1	End	76,083,666 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

right frontal lobe

Brodmann area 9

anterior cingulate cortex

anterior pituitary

mucosa of transverse colon

prefrontal cortex

Hypothalamus

apex of heart

Amygdala

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	extracellular ligand-gated ion channel activity zinc ion binding ligand-gated ion channel activity ion channel activity serotonin-gated cation-selective channel activity transmembrane signaling receptor activity
Cellular component	integral component of membrane plasma membrane membrane integral component of plasma membrane neuron projection synapse
Biological process	response to zinc ion ion transport signal transduction ion transmembrane transport serotonin receptor signaling pathway chemical synaptic transmission regulation of membrane potential nervous system process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


353174


n/a

Ensembl


ENSG00000186919


n/a

UniProt


Q401N2


n/a

RefSeq (mRNA)


NM_180990


n/a

RefSeq (protein)


NP_851321


n/a

Location (UCSC)

Chr 17: 76.07 – 76.08 Mb

n/a

PubMed search

n/a

Wikidata

View/Edit Human

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach. The endogenous ligand for ZAC is thought to be Zn, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.

References

^ GRCh38: Ensembl release 89: ENSG00000186919 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davies PA, Wang W, Hales TG, Kirkness EF (January 2003). "A novel class of ligand-gated ion channel is activated by Zn2+". The Journal of Biological Chemistry. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (September 2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochemical and Biophysical Research Communications. 335 (2): 277–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.

Ion channel, cell surface receptor: ligand-gated ion channels

Cys-loop receptors

5-HT/serotonin	5-HT₃ A B C D E
GABA	GABA_A α₁ α₂ α₃ α₄ α₅ α₆ β₁ β₂ β₃ γ₁ γ₂ γ₃ δ ε π θ GABA_A-ρ ρ₁ ρ₂ ρ₃
Glycine	α₁ α₂ α₃ α₄ β
Nicotinic acetylcholine	monomers: α1 α2 α3 α4 α5 α6 α7 α9 α10 β1 β2 β3 β4 δ ε pentamers: (α3)₂(β4)₃ (α4)₂(β2)₃ (α7)₅ (α1)₂(β4)₃ - Ganglion type (α1)₂β1δε - Muscle type
Zinc	Zinc-activated

Ionotropic glutamates

Ligand-gated only	AMPA (1 2 3 4) Kainate 1 2 3 4 5
Voltage- and ligand-gated	NMDA 1 2A 2B 2C 2D 3A 3B L1A L1B
‘Orphan’	GluD δ₁ δ₂

ATP-gated channels

Purinergic receptors	P2X 1 2 3 4 5 6 7

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