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ZDHHC8
Identifiers
Aliases	ZDHHC8, DHHC8, ZDHHCL1, ZNF378, zinc finger DHHC-type containing 8, zinc finger DHHC-type palmitoyltransferase 8
External IDs	OMIM: 608784; MGI: 1338012; HomoloGene: 8363; GeneCards: ZDHHC8; OMA:ZDHHC8 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.21 Start 20,129,456 bp End 20,148,007 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve right hemisphere of cerebellum stromal cell of endometrium anterior pituitary right ovary apex of heart right lobe of thyroid gland left lobe of thyroid gland granulocyte right frontal lobe n/a More reference expression data BioGPS n/a
Gene ontology Molecular function palmitoyltransferase activity transferase activity acyltransferase activity protein-cysteine S-palmitoyltransferase activity Cellular component integral component of membrane Golgi apparatus cytoplasmic vesicle membrane mitochondrion membrane cytoplasmic vesicle cytosol Biological process protein palmitoylation locomotory behavior high-density lipoprotein particle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29801 27801 Ensembl ENSG00000099904 ENSMUSG00000060166 UniProt Q9ULC8 Q5Y5T5 RefSeq (mRNA) NM_001185024 NM_013373 NM_172151 RefSeq (protein) NP_001171953 NP_037505 NP_742163 NP_001365948 Location (UCSC) Chr 22: 20.13 – 20.15 Mb n/a PubMed search
Wikidata
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ZDHHC8 is a putative palmitoyltransferase enzyme containing a DHHC domain that in humans is encoded by the ZDHHC8 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000099904 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
5. Mukai J, Liu H, Burt RA, Swor DE, Lai WS, Karayiorgou M, Gogos JA (Jun 2004). "Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia". Nat Genet. 36 (7): 725–31. doi:10.1038/ng1375. PMID 15184899.
6. "Entrez Gene: ZDHHC8 zinc finger, DHHC-type containing 8".

Further reading

• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Chen WY, Shi YY, Zheng YL, et al. (2005). "Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8". Hum. Mol. Genet. 13 (23): 2991–5. doi:10.1093/hmg/ddh322. PMID 15489219.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Saito S, Ikeda M, Iwata N, et al. (2005). "No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population". Neurosci. Lett. 374 (1): 21–4. doi:10.1016/j.neulet.2004.10.015. PMID 15631889. S2CID 24312967.
• Glaser B, Schumacher J, Williams HJ, et al. (2005). "No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples". Biol. Psychiatry. 58 (1): 78–80. doi:10.1016/j.biopsych.2005.03.017. PMID 15992527. S2CID 20264569.
• Otani K, Ujike H, Tanaka Y, et al. (2006). "The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia". Neurosci. Lett. 390 (3): 166–70. doi:10.1016/j.neulet.2005.08.019. PMID 16150541. S2CID 26919027.
• Demily C, Legallic S, Bou J, et al. (2007). "ZDHHC8 single nucleotide polymorphism rs175174 is not associated with psychiatric features of the 22q11 deletion syndrome or schizophrenia". Psychiatr. Genet. 17 (5): 311–2. doi:10.1097/YPG.0b013e328133f369. PMID 17728672.

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