ZK-283197 - Misplaced Pages

Chemical compound Pharmaceutical compound

ZK-283197
Clinical data

Other names	BAY 86-5310; SH-T04211C; ZK283197
Routes of administration	By mouth
Drug class	Estrogen; Selective ERβ agonist
Legal status
Legal status	Investigational
Identifiers
CAS Number	634910-57-9 1644565-93-4
PubChem CID	9839931
PubChem SID	381127857
UNII	G4AK6B5BV6
Chemical and physical data
Formula	C₂₀H₂₅FO₂
Molar mass	316.416 g·mol
3D model (JSmol)	Interactive image
SMILES C12CC3((1C(2F)O)CCC4=C3C=CC(=C4)O)C=C
InChI InChI=1S/C20H25FO2/c1-3-20-9-8-19(2)16(11-17(23)18(19)21)15(20)6-4-12-10-13(22)5-7-14(12)20/h3,5,7,10,15-18,22-23H,1,4,6,8-9,11H2,2H3/t15-,16-,17+,18-,19-,20+/m0/s1 Key:LXLNOGZWGYFWQV-CFSBILQPSA-N

ZK-283197 (also known as BAY 86-5310 or SH-T04211C) is a selective and orally active ERβ agonist which was under development by Bayer Healthcare AG for the treatment of vasomotor symptoms. It reached phase II clinical trials prior to the discontinuation of its development. Its development was terminated in 2014.

References

^ "ZK 283197". AdisInsight. Springer Nature Switzerland AG.
US 332204, Pietras RJ, Jung ME, "Methods of using estrogen receptor-beta ligands as radiation mitigators", published 2015-01-15

ERTooltip Estrogen receptor

Agonists

Mixed
(SERMsTooltip Selective estrogen receptor modulators)

Antagonists

GPERTooltip G protein-coupled estrogen receptor

Agonists	2-Methoxyestradiol 7β-Hydroxyepiandrosterone Afimoxifene (4-hydroxytamoxifen) Aldosterone Atrazine Bisphenol A Daidzein DDT (p,p'-DDT, o',p'-DDE) Diarylpropionitrile Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs (2,2',5'-PCB-4-OH) Propylpyrazoletriol Quercetin Raloxifene Resveratrol STX Tamoxifen Tectoridin
Antagonists	CCL18 Estriol G-15 G-36 MIBE
Unknown	Diethylstilbestrol Zearalenone

See also: Receptor/signaling modulators; Estrogens and antiestrogens; Androgen receptor modulators; Progesterone receptor modulators; List of estrogens

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