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ZNF592
Identifiers
Aliases	ZNF592, CAMOS, SCAR5, zinc finger protein 592
External IDs	OMIM: 613624; MGI: 2443541; HomoloGene: 8759; GeneCards: ZNF592; OMA:ZNF592 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q25.3 Start 84,748,592 bp End 84,806,445 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 D3 Start 80,643,429 bp End 80,694,912 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell tibialis anterior muscle mucosa of ileum gastrocnemius muscle muscle of thigh bone marrow cells granulocyte blood sural nerve deltoid muscle Top expressed in zygote secondary oocyte primary oocyte otic vesicle granulocyte otolith organ utricle tail of embryo mesenteric lymph nodes ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9640 233410 Ensembl ENSG00000166716 ENSMUSG00000005621 UniProt Q92610 Q8BHZ4 RefSeq (mRNA) NM_014630 NM_178707 RefSeq (protein) NP_055445 NP_848822 Location (UCSC) Chr 15: 84.75 – 84.81 Mb Chr 7: 80.64 – 80.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 592 is a protein that in humans is encoded by the ZNF592 gene.

Function

This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000166716 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000005621 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 592". Retrieved 2016-03-07.

Further reading

• Huang J, Zheng DL, Qin FS, Cheng N, Chen H, Wan BB, Wang YP, Xiao HS, Han ZG (2010). "Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling". J. Clin. Invest. 120 (1): 223–41. doi:10.1172/JCI38012. PMC 2798676. PMID 20038795.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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