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Zabofloxacin

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Zabofloxacin
Names
Preferred IUPAC name 1-Cyclopropyl-6-fluoro-7-octan-6-yl]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Other names DW-224a
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C19H20FN5O4/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28)/b23-14-Key: ZNPOCLHDJCAZAH-UCQKPKSFSA-N
  • InChI=1/C19H20FN5O4/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28)/b23-14-Key: ZNPOCLHDJCAZAH-UCQKPKSFBL
SMILES
  • Fc1c(nc2c(c1)C(=O)C(\C(=O)O)=C/N2C3CC3)N5C\C(=N\OC)C4(CNC4)C5
Properties
Chemical formula C19H20FN5O4
Molar mass 401.392
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Zabofloxacin (DW-224a) is an investigational fluoroquinolone antibiotic for multidrug-resistant infections due to Gram-positive bacteria. It also has activity against Neisseria gonorrhoeae including strains that are resistant to other quinolone antibiotics.

Zabofloxacin was discovered by Dong Wha Pharmaceuticals and licensed to Pacific Beach BioSciences for development.

A double-blind, three-arm clinical study of the drug began in March 2010.

References

  1. HyeKyung Han; Sung Eun Kim; Kwang-Hee Shin; Cheolhee Lim; Kyoung Soo Lim; Kyung-Sang Yu; Joo-Youn Cho (October 2013). "Comparison of pharmacokinetics between new quinolone antibiotics: the zabofloxacin hydrochloride capsule and the zabofloxacin aspartate tablet". Current Medical Research and Opinion. 29 (10): 1349–1355. doi:10.1185/03007995.2013.825591. PMID 23865727. S2CID 11071210.
  2. Jong-Hwa Lee; Jung-Heun Ha; Dae-Hun Park; Dong-Rack Choi; Gye-Won Lee; Sung-Hoon Ahn & Choong-Yong Kim (2014). "Quantification Of Zabofloxacin In Rat Plasma Using Hplc-Uv Detector And Its Application To A Pharmacokinetic Study". Journal of Liquid Chromatography & Related Technologies. 37 (3): 311–320. doi:10.1080/10826076.2012.745137. S2CID 96104286.
  3. Kim EJ, Shin WH, Kim KS, Han SS (Nov 2004). "Safety pharmacology of DW-224a, a novel fluoroquinolone antibiotic agent". Drug Chem Toxicol. 27 (4): 295–307. doi:10.1081/DCT-200039708. PMID 15573468. S2CID 13284436.
  4. Park, Hee-Soo; Oh, Sang-Hun; Kim, Hye-Shin; Choi, Dong-Rack; Kwak, Jin-Hwan (2016-11-17). "Antimicrobial Activity of Zabofloxacin against Clinically Isolated Streptococcus pneumoniae". Molecules. 21 (11): 1562. doi:10.3390/molecules21111562. ISSN 1420-3049. PMC 6273590. PMID 27869677.
  5. Jones RN, Biedenbach DJ, Ambrose PG, Wikler MA (2008). "Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains". Diagn Microbiol Infect Dis. 62 (1): 110–112. doi:10.1016/j.diagmicrobio.2008.05.010. PMID 18620833.
  6. "Pacific Beach BioSciences and Dong Wha Pharmaceuticals Sign Exclusive License Agreement to Develop and Commercialize Zabofloxacin (PB-101, DW-224a)". GlobeNewswire. August 10, 2007. Archived from the original on March 3, 2016. Retrieved March 27, 2014.
  7. IASO Pharma Inc. (2012-05-04). "A Phase 2, Multi-Dose, Double-Blind, Double-Dummy, Active-Control, Randomized Study to Evaluate the Safety, Efficacy and Pharmacokinetic Profile of Two Dosing Regimens of Zabofloxacin for the Treatment of Community-Acquired Pneumonia of Moderate Severity". Archived from the original on 2022-11-18. Retrieved 2022-11-18.

External links

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